sc SC-560
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- 更新時(shí)間 2019/7/11 18:12:02
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抑制劑，調(diào)節(jié)劑，API，天然產(chǎn)物，各種類(lèi)型化合物庫(kù)
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL；5 mg；10 mg |
|---|---|---|---|
| 貨號(hào) | HY-59105 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
SC-560
產(chǎn)品活性：SC-560是有效，選擇性的 COX-1 抑制劑，IC50 值為9 nM。
研究領(lǐng)域：Immunology/Inflammation
作用靶點(diǎn)：COX
In Vitro: Preincubation of COX-1 with SC-560 inhibits the conversion of arachidonic acid to PGE2 in a concentration-dependent manner. The IC50 of SC-560 for COX-2 is 6.3 μM, nearly 1,000-fold higher than with COX-1. SC-560 shows a dose and time dependent inhibitory effect on HCC cell growth. SC-560 also inhibits colony formation in soft agar and induces apoptosis in HCC cells in a dose-dependent manner. Moreover, SC-560 decreases the levels of the anti-apoptotic proteins survivin and XIAP and activates caspase 3 and 7 in a dose and time dependent fashion.
In Vivo: Oral dosing with either 10 or 30 mg/kg SC-560 1 hour before assay completely inhibits ionophore-stimulated TxB2production, indicating that SC-560 is orally bioavailable and inhibits COX-1 in vivo. SC-560 extensively distributes into rat tissues, and has a CL approaching hepatic plasma flow. The drug displays low less than 15% and formulation dependent bioavailability after oral administration and demonstrates kidney toxicity.
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