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細胞膜標志物

閱讀：109 發(fā)布時間：2024-11-29
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細胞膜標志物
細胞膜是細胞的外部結(jié)構(gòu)，是防止細胞外物質(zhì)自由進入細胞的屏障，它不僅為細胞提供物理保護，還負責控制物質(zhì)的進出、細胞間通訊以及許多其他重要功能。細胞膜主要由磷脂雙分子層構(gòu)成，其中包含蛋白質(zhì)、膽固醇和糖分子。磷脂雙分子層由兩個磷脂分子層組成，疏水性的脂肪酸尾部朝內(nèi)，親水性的頭部朝外形成一個半透膜。
細胞間黏附分子（Cell Adhesion Molecules,CAMs）、受體酪氨酸激酶（Receptor Tyrosine Kinases,RTKs）和離子通道蛋白等細胞膜標志物在細胞功能和信號轉(zhuǎn)導中起關(guān)鍵作用。CAMs是一類膜蛋白，具有細胞黏附、細胞間通信和信號傳導的功能。RTKs是一類跨膜受體蛋白，能夠通過受體激酶活化細胞內(nèi)的信號通路。常見的RTKs包括表皮生長因子受體（EGFR）、血小板源性生長因子受體（PDGFR）和神經(jīng)生長因子受體（NGFR）等。離子通道蛋白是一類位于細胞膜上的蛋白質(zhì)，它們形成了穿越細胞膜的通道，能夠調(diào)節(jié)細胞內(nèi)外離子的平衡。常見的離子通道蛋白包括鈉、鉀和鈣通道等，它們對于維持細胞的電生理特性和信號轉(zhuǎn)導至關(guān)重要，并且參與神經(jīng)傳導、肌肉收縮和心臟節(jié)律等生理過程。
ATP1A1編碼的蛋白屬于p型陽離子轉(zhuǎn)運ATP酶家族和Na+/K+ - ATP酶亞家族。ATP1A1是活性酶的催化成分，可催化ATP的水解，并通過質(zhì)膜交換鈉離子和鉀離子。這一作用產(chǎn)生了鈉離子和鉀離子的電化學梯度，為各種營養(yǎng)物質(zhì)的主動運輸提供能量。
圖1 ATP1A1抗體免疫組化結(jié)果示意圖
（商品貨號：K111558P）
CDH3基因位于16號染色體長臂區(qū)域的一個基因簇中，編碼鈣粘蛋白超家族中的一種經(jīng)典鈣粘蛋白。鈣粘蛋白是一種依賴鈣的細胞粘附蛋白，它們在連接細胞時優(yōu)先以親同性的方式相互作用，鈣粘蛋白可能有助于異質(zhì)細胞類型的分選。
圖3 CDH3抗體免疫組化結(jié)果示意圖
（商品貨號：K111121P）

已有一些蛋白被鑒定可用作細胞膜標志物（見表1）。

表 1 細胞膜標志物

相關(guān)產(chǎn)品
產(chǎn)品貨號
產(chǎn)品名稱
K109982P
Anti-ATP1A1 Polyclonal Antibody
K110469P
Anti-ATP1A1 Polyclonal Antibody
K111558P
Anti-ATP1A1 Polyclonal Antibody
K005524P
Anti-ATP1A1 Polyclonal Antibody
K007644P
Anti-ATP1A1 Polyclonal Antibody
K111556P
Anti-ATP1A2 Polyclonal Antibody
K004215P
Anti-ATP1B1 Polyclonal Antibody
K106561P
Anti-CADH1 Polyclonal Antibody
K010592M
Anti-CD26(APC)
Monoclonal Antibody
K010787M
Anti-CD26(FITC)
Monoclonal Antibody
K011048M
Anti-CD26(PE)
Monoclonal Antibody
K115158P
Anti-CDH1 Polyclonal Antibody
K002267P
Anti-CDH1 Polyclonal Antibody
K111121P
Anti-CDH3 Polyclonal Antibody
K008218P
Anti-CDH3 Polyclonal Antibody
K111282P
Anti-CDH5 Polyclonal Antibody
K001742P
Anti-CDH5 Polyclonal Antibody
K106786P
Anti-DPP4 Polyclonal Antibody
K002791P
Anti-DPP4 Polyclonal Antibody
K011355P
Anti-E-Cadherin
Polyclonal Antibody
K000137M
Anti-EGFR Monoclonal Antibody
K000139M
Anti-EGFR Monoclonal Antibody
K000140M
Anti-EGFR Monoclonal Antibody
K106563P
Anti-EGFR Polyclonal Antibody
K112830P
Anti-EGFR Polyclonal Antibody
K112831P
Anti-EGFR Polyclonal Antibody
K002208P
Anti-EGFR Polyclonal Antibody
K002209P
Anti-EGFR Polyclonal Antibody
K002298P
Anti-EGFR Polyclonal Antibody
K002300P
Anti-EGFR Polyclonal Antibody
K009458P
Anti-EGFR Polyclonal Antibody
K009564P
Anti-EGFRvII
Polyclonal Antibody
K009589P
Anti-phospho-CTNNB1(Ser33+37)
Polyclonal Antibody
K006171P
Anti-Phospho-EGFR-T669
Polyclonal Antibody
K006212P
Anti-Phospho-EGFR-Y1068
Polyclonal Antibody
K006173P
Anti-Phospho-EGFR-Y1148
Polyclonal Antibody
K006169P
Anti-Phospho-EGFR-Y845
Polyclonal Antibody
K006172P
Anti-Phospho-EGFR-Y992
Polyclonal Antibody
K006172P
Anti-Phospho-EGFR-Y992
Polyclonal Antibody

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細胞膜標志物

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產(chǎn)品貨號	產(chǎn)品名稱
K109982P	Anti-ATP1A1 Polyclonal Antibody
K110469P	Anti-ATP1A1 Polyclonal Antibody
K111558P	Anti-ATP1A1 Polyclonal Antibody
K005524P	Anti-ATP1A1 Polyclonal Antibody
K007644P	Anti-ATP1A1 Polyclonal Antibody
K111556P	Anti-ATP1A2 Polyclonal Antibody
K004215P	Anti-ATP1B1 Polyclonal Antibody
K106561P	Anti-CADH1 Polyclonal Antibody
K010592M	Anti-CD26(APC) Monoclonal Antibody
K010787M	Anti-CD26(FITC) Monoclonal Antibody
K011048M	Anti-CD26(PE) Monoclonal Antibody
K115158P	Anti-CDH1 Polyclonal Antibody
K002267P	Anti-CDH1 Polyclonal Antibody
K111121P	Anti-CDH3 Polyclonal Antibody
K008218P	Anti-CDH3 Polyclonal Antibody
K111282P	Anti-CDH5 Polyclonal Antibody
K001742P	Anti-CDH5 Polyclonal Antibody
K106786P	Anti-DPP4 Polyclonal Antibody
K002791P	Anti-DPP4 Polyclonal Antibody
K011355P	Anti-E-Cadherin Polyclonal Antibody
K000137M	Anti-EGFR Monoclonal Antibody
K000139M	Anti-EGFR Monoclonal Antibody
K000140M	Anti-EGFR Monoclonal Antibody
K106563P	Anti-EGFR Polyclonal Antibody
K112830P	Anti-EGFR Polyclonal Antibody
K112831P	Anti-EGFR Polyclonal Antibody
K002208P	Anti-EGFR Polyclonal Antibody
K002209P	Anti-EGFR Polyclonal Antibody
K002298P	Anti-EGFR Polyclonal Antibody
K002300P	Anti-EGFR Polyclonal Antibody
K009458P	Anti-EGFR Polyclonal Antibody
K009564P	Anti-EGFRvII Polyclonal Antibody
K009589P	Anti-phospho-CTNNB1(Ser33+37) Polyclonal Antibody
K006171P	Anti-Phospho-EGFR-T669 Polyclonal Antibody
K006212P	Anti-Phospho-EGFR-Y1068 Polyclonal Antibody
K006173P	Anti-Phospho-EGFR-Y1148 Polyclonal Antibody
K006169P	Anti-Phospho-EGFR-Y845 Polyclonal Antibody
K006172P	Anti-Phospho-EGFR-Y992 Polyclonal Antibody
K006172P	Anti-Phospho-EGFR-Y992 Polyclonal Antibody