目錄:北京索萊寶科技有限公司>>抗體>>Polyclonal Antibody>> K106389PAnti-GAPDH Polyclonal Antibody
| 供貨周期 | 現貨 | 規格 | 50ul/100ul |
|---|---|---|---|
| 貨號 | K106389P | 應用領域 | 醫療衛生,環保,化工,生物產業,農業 |
| 主要用途 | WB |
Anti-GAPDH Polyclonal Antibody
| 英文名稱 | Anti-GAPDH Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | GAPD;CDABP0047;OK/SW-cl.12;G3PD;HEL-S-162eP |
| 應用 | WB |
| 稀釋比例 | WB 1:5000. |
| 蛋白分子量 | 36kDa |
| Gene ID | 2597 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human GAPDH |
| 性狀 | 液體 |
Public Immunogen Range |
Recombinant protein of human GAPDH |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | P04406 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis. As well as functioning as a glycolytic enzyme in cytoplasm, recent evidence suggests that mammalian GAPDH is also involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of data appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. It is constitutively expressed in almost all tissues at high levels. There are however some physiological factors such as hypoxia and diabetes that increase GAPDH expression in certain cell types. GAPDH molecule is composed of four 36kDa subunits. |
多克隆抗體
抗原通常是由多個抗原決定簇組成的，由一種抗原決定簇刺激機體，由一個B淋巴細胞接受該抗原所產生的抗體稱之為單克隆抗體（Monclone antibody）。由多種抗原決定簇刺激機體，相應地就產生各種各樣的單克隆抗體，這些單克隆抗體混雜在一起就是多克隆抗體（Polyclonal antibody），機體內所產生的抗體就是多克隆抗體。
由于多克隆抗體通常包含抗某一抗原的不同表位的抗體，所以，在深固定的樣本中也會很好地發揮效應，在石蠟包埋組織切片的染色中，多克隆抗體選用。根據實驗的不同需要，多克隆抗體應用于相應抗原的標記。此外，在農業生產中，多克隆抗體被用于農藥殘留現場監測；在臨床應用中，多克隆抗體主要用于病原物的檢測、疾病的診斷及治療，如作為蛋白類免疫抑制劑用于移植反應和自身免疫病的治療。
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