基于斑馬魚的體內實驗應用有大量的已開發的人類疾病斑馬魚模型如：
1.代謝綜合癥：肥胖 (內臟肥胖)、 血脂異常、脂肪肝、糖耐受失調
2.人類癌癥細胞異種移植：腫瘤血管生成、遠端轉移
3.循環疾病：心力衰竭、藥物誘導的心率失調
4.中央神經系統失調：耳聾、視力障礙、嗅覺失調、癲癇、發育紊亂、睡眠喚醒障礙、肌營養不良 (ALS)

下載實驗案例

參考文獻：
1. Zhang, B., et al., Quantitative phenotyping-based in vivo chemical screening

in a zebrafish model of leukemia stem cell xenotransplantation, PLoS One,

2014 Jan 15; 9(1).
2. Umemoto, N., et al., Fluorescent-based methods for gene knockdown and

functional cardiac imaging in zebrafish, Mol Biotechnol, 2013 Oct; 55(2): 131-

42.
3. Kanungo, J., et al., In vivo imaging and quantitative analysis of changes in

axon length using transgenic zebrafish embryos. Neurotoxicol Teratol, 2011

Nov-Dec; 33(6): 618-23.
4. Diekmann, H., et al., Characterization of optic nerve regeneration using

transgenic zebrafish. Front Cell Neurosci, 2015 April 9; 9:118.
5. Huan, H., et al., High-throughput screening for bioactive molecules using

primary cell culture of transgenic zebrafish embryos. Cell Rep, 2012 Sep 27;

2(3):695-704.

歡迎關注*微信