詳細(xì)介紹
FormuMax Scientific F70101C-A代理現(xiàn)貨
產(chǎn)品名稱 | 產(chǎn)品編號 | 規(guī)格 | 儲存 | 價格(元) |
Clophosome®-Clodronate Liposomes (Neutral) 中性氯氟松(體內(nèi)巨噬細(xì)胞清除劑) | 40335ES05 | 2ml | 4℃ | 2566.00 |
Clophosome®-Clodronate Liposomes (Neutral) 中性氯氟松(體內(nèi)巨噬細(xì)胞清除劑) | 40335ES10 | 10ml | 4℃ | 8566.00 |
產(chǎn)品描述
Clophosome®(氯氟松)是目前市場上的用于高效巨噬細(xì)胞耗竭的氯磷酸二鈉脂質(zhì)體。靜脈注射0.2ml Clophosome®-Clodronate Liposomes,24hr后脾臟(紅髓巨噬細(xì)胞)中巨噬細(xì)胞清除率達(dá)到80%-90%。Clophosome分子包被在小MLV脂質(zhì)體膠囊中,具有活性高、穩(wěn)定性高及使用方便等特點(diǎn)。Clophosome®中裝載的氯膦酸二鈉是一種特異的殺傷巨噬細(xì)胞的藥物,可以通過誘導(dǎo)巨噬細(xì)胞凋亡來剔除組織中的巨噬細(xì)胞。Clophosome®-Clodronate Liposomes在長期保存后仍能保持均勻的、自由流動狀態(tài),不粘稠、易于注射。該產(chǎn)品為無菌生產(chǎn)。
Clophosome®-Clodronate Liposomes適用于多種注射方式,如靜脈注射、腹腔注射、皮下注射、鼻內(nèi)注射等。
FormuMax Scientific F70101C-A代理現(xiàn)貨
運(yùn)輸與保存方法
產(chǎn)品4℃保存。冰袋運(yùn)輸。不能凍存!使用前一定要充分混勻并恢復(fù)到室溫。
注意事項(xiàng)
1.為了您的安全和健康,請穿實(shí)驗(yàn)服并戴一次性手套操作。
2.使用前一定要充分混勻并恢復(fù)到室溫。
產(chǎn)品使用
使用前,可使用PBS稀釋至工作濃度。
巨噬細(xì)胞清除時,推薦起始劑量為0.15-0.2 ml/20-25g動物體重(i.v.或i.p.)。具體劑量需根據(jù)實(shí)驗(yàn)進(jìn)一步優(yōu)化。
注:需要清除巨噬細(xì)胞超過一周時:第1天注射200 µL (20-25g體重)。為得到更加*的結(jié)果,提前注射2天。為更長時間的清除巨噬細(xì)胞,第1次注射 200 µL,每4天注射100 µL。
Clophosome®-A- Clodronate liposomes (Anionic)
Clophosome®-A, negatively-charged Clodronate liposomes, offers superior efficiency of macrophagedepletion. Clodronate molecules are encapsulated in LUV liposomes for superior activity, physical and chemical stABIlity, and convenience of use. It is formulated to an exceptionally highClodronate/lipid ratio. Free Clodronate is cleaned out and the Liposomal encapsulation efficiency of Clodronateis more than 90%.Clophosome liposomes remain homogenous even after long term storage in fridge. It is not viscous and easy to inject even with fine needles.It is manufactured sterilefor long term shelf-life.
The product is suitable for dosing with various routes includingintravenous, intraperitoneal, subcutaneous, intranasal,intratracheal and etc. We have achieved > 90%depletion in splenicmacrophages (red pulp macrophages) 24 hours after a single 0.2 mL intravenous injection.A starting dose of 0.15-2 mL (i.v. or i.p.) for 20-25ganimal body weight is recommended for good consistency in macrophage depletion. Optimization is recommended for specific applications.