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This mouse monoclonal antibody was generated against a ΦX174 bacteriophage-derived synthetic DNA–RNA antigen and recognizes RNA-DNA hybrids of various lengths.
Highlights:
- Useful in the detection of R-loops
- High specificity and affinity for DNA-RNA hybrids
- Does NOT cross-react with single-stranded DNA or double-stranded DNA
- Minor cross-reaction (~5-fold less) has been observed for AU-rich double-stranded RNA.
- High affinity binding shown for hybrids of 8, 10, 15, and 23 base pairs in length
DNA-RNA hybrids are a natural occurrence within eukaryotic cells, with levels of these hybrids increasing at sites with high transcriptional activity, such as during transcription initiation, repression, and elongation. Because RNA-DNA hybrids influence genomic instability, the S9.6 antibody is a useful reagent to help study the consequences of R-loops and lesions formed by these hybrids during DNA replication or other cellular processes. In addition, the S9.6 antibody is effective in recognizing RNA-DNA hybridization for microarray studies.
| Product Type: | Antibody |
| Name: | Anti-DNA-RNA Hybrid [S9.6] |
| Antigen: | S9.6 ΦX174 bacteriophage-derived synthetic DNA–RNA antigen |
| Isotype: | Mouse IgG2a |
| Clonality: | Monoclonal |
| Clone Name: | S9.6 |
| Reactivity: | High specificity and affinity for DNA/RNA hybrids and other A-form nucleic acid hybrids |
| Immunogen: | ΦX174 bacteriophage-derived synthetic DNA/RNA |
| Species Immunized: | BALB/c mouse |
| Paratope: | DYYGSRWFDY (proposed) |
| Purification Method: | Protein A/G |
| Buffer: | PBS, 0.05% (w/v) Sodium Azide |
| Tested Applications: | Immunoblot/Immunoprecipitation, Chip/Chip-seq, Immunocytochemistry, Immunofluorescence, DNA-RNA Immunoprecipitation (DRIP) |
| Storage: | -20C (avoid repeated freeze-thaw cycles) |
| Shipped: | Cold packs |
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