MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。

MnTE-2-PyP chloride

CAS No. : 219818-60-7

產(chǎn)品活性：MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer.

研究領(lǐng)域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶點(diǎn)：Reactive Oxygen Species

In Vitro: MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation.
MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively.
MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment.
MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding.

In Vivo: MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer.
MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model.

相關(guān)產(chǎn)品：D-α-Hydroxyglutaric acid disodium  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  7-Hydroxy-4-methyl-2(1H)-quinolone  |  N-tert-Butyl-α-phenylnitrone-d₁₄  |  BDP 581/591 NHS ester  |  Cysteamine-d₄ (hydrochloride)  |  L-Ascorbic acid sodium salt  |  Manganese(salen) chloride  |  Hydroxyphenyl Fluorescein  |  Glucosamine sulfate  |  Maresin 1  |  Berberine  |  1,3-Dicaffeoylquinic acid  |  Ciprofloxacin  |  Echinocystic acid  |  Lacto-N-fucopentaose I  |  Nisoldipine-d₆  |  Arg-Tyr  |  HKPerox-2  |  3-Indolepropionic acid  |  2-Methoxyestradiol-¹³C,d₃  |  Albendazole  |  QD394  |  AKBA  |  Cedrin  |  Deferoxamine  |  Ellagic acid  |  Acetylcysteine-d₃  |  N-Acetyl-D-cysteine  |  L-Ascorbic acid-¹³C₆

熱門(mén)產(chǎn)品線：重組蛋白  |  化合物庫(kù)  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物  |  寡核苷酸  |  抗體  |  點(diǎn)擊化學(xué)

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫(kù)，我們致力于為*科研客戶提供前沿的高品質(zhì)小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動(dòng)劑涉及各熱門(mén)信號(hào)通路及疾病領(lǐng)；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應(yīng)用于新藥研發(fā)、生命科學(xué)等科研項(xiàng)目；
•   提供虛擬篩選，離子通道篩選，代謝組學(xué)分析檢測(cè)分析，藥物篩選等專業(yè)技術(shù)服務(wù)；
•   設(shè)有專業(yè)的實(shí)驗(yàn)中心和嚴(yán)格的質(zhì)控、驗(yàn)證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項(xiàng)質(zhì)檢報(bào)告，確保產(chǎn)品的高純度、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國(guó)客戶實(shí)驗(yàn)驗(yàn)證；
•   Nature, Cell, Science 等多種頂級(jí)期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團(tuán)隊(duì)跟蹤最新的制藥及生命科學(xué)研究進(jìn)展，為您提供*新的活性化合物；
•   與世界各大制藥公司及著名科研機(jī)構(gòu)建立了長(zhǎng)期的合作。