MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

Temsavir

CAS No. : 701213-36-7

產品活性：Temsavir (BMS-626529) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4⁺ T cells.

研究領域：Anti-infection

作用靶點：HIV

In Vitro: Temsavir has half-maximal effective concentration (EC₅₀) values of <10 nM against the vast majority of viral isolates. Temsavir exhibits an average EC₅₀ against LAI virus of 0.7±0.4 nM. Temsavir exhibits an EC₅₀ of 0.01 nM against the most susceptible virus and an EC₅₀ of >2,000 nM against the least susceptible virus. The cytotoxicity profile of Temsavir is examined in several cell types from different human tissues. CC₅₀ values of >200 μM are observed in MT-2 (T lymphocytes), HEK293 (kidney), HEp-2 (larynx), HepG2 (liver), HeLa (cervix), HCT116 (colorectal), MCF-7 (breast), SK-N-MC (neuroepithelium), HOS (bone), H292 (lung), and MDBK (bovine kidney) cells measured after 3 or 6 days in culture. CC₅₀ values of 105 and 192 μM are obtained in the T-cell line PM1 and in PBMCs, respectively, following 6 days in culture. These results show that Temsavir exhibits low cytotoxicity in cell culture. Temsavir exhibits a broad spectrum of antiviral activity against a panel of clinical isolates, with a 50% inhibitory concentration (IC₅₀) ranging from subnanomolar levels to >0.1 µM.

相關產品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Clinical Compound Library  |  Antiviral Compound Library  |  Peptidomimetic Library  |  Human Metabolite Library  |  Peldesine dihydrochloride  |  Abacavir sulfate  |  HIV-IN-6  |  Epicoccone B  |  Ditiocarb  |  Nevirapine  |  DAPTA  |  Aloperine  |  Elipovimab  |  HIV-1 inhibitor-52  |  PMEDAP  |  Integracin B  |  FNC-TP  |  DDX3-IN-1  |  Sennoside A  |  CK-666  |  HIV-1 inhibitor-44  |  Flavopiridol  |  Claficapavir  |  Atazanavir  |  1-Deoxymannojirimycin hydrochloride  |  TC14012  |  (Z)-9-Propenyladenine  |  Apabetalone  |  CCR5 antagonist 2  |  2F5 epitope  |  HIV-1 inhibitor-23  |  Apelin-36(rat, mouse)  |  MIV-150  |  Tenofovir alafenamide hemifumarate

熱門產品線：重組蛋白  |  化合物庫  |  天然產物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領；
•   產品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產品，廣泛應用于新藥研發、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業技術服務；
•   設有專業的實驗中心和嚴格的質控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
•   產品的生物活性多經各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業團隊跟蹤最新的制藥及生命科學研究進展，為您提供*新的活性化合物；
•   與世界各大制藥公司及著名科研機構建立了長期的合作。