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目錄:MedChemExpress LLC>>生化試劑>> SC66 | MCE

SC66 | MCE
  • SC66 | MCE
參考價 550
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參考價 550
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  • 品牌 MedChemExpress (MCE)
  • 型號
  • 廠商性質 生產商
  • 所在地 國外
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更新時間:2023-06-15 09:34:05瀏覽次數:147評價

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CAS 871361-88-5 純度 99.88%
分子量 276.33 分子式 C??H??N?O
供貨周期 現貨 規格 5 mg
貨號 HY-19832 應用領域 醫療衛生,化工,生物產業,制藥
SC66 | MCESC66 is an <b>Akt</b> inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.

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SC66

CAS No. : 871361-88-5

產品活性:SC66 is an Akt inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.

研究領域:PI3K/Akt/mTOR  |  Apoptosis

作用靶點:Akt  |  Apoptosis

In Vitro: SC66 inhibits cell viability and colony forming capacity of HCC cells with IC50s of 0.77,0.47,0.92,0.75 and 2.85 μg/mL at 72 hours for HepG2, Hep3B, PLC/PRF/5,HA22T/VGH and Huh7 cells. HepG2, HA22T/VGH and PLC/PRF/5 cells have similar IC50s of approximately 0.85 and 0.75 μg/mL at 48 and 72 hours, respectively. To determine whether the decrease in cell viability is related to apoptosis induction, TUNEL assays are performed in Hep3B and Huh7 cells treated with 1, 2 and 4 μg/mL of SC66 for 24 hours. In Hep3B cells the number of TUNEL-positive cells increased with increasing concentrations of SC66, whereas in Huh7 cells very few light brown-colored cells are observed only after treatment with 4 μg/mL SC66.

In Vivo: To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm3, mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group.

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