目錄:MedChemExpress LLC>>生化試劑>> VAS2870 | MCE
CAS | 722456-31-7 | 純度 | 98.45% |
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分子量 | 360.39 | 分子式 | C??H??N?OS |
供貨周期 | 現貨 | 規格 | 5 mg |
貨號 | HY-12804 | 應用領域 | 醫療衛生,化工,生物產業,制藥 |
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CAS No. : 722456-31-7
產品活性:VAS2870 is a NADPH oxidase (NOX) inhibitor.
研究領域:Metabolic Enzyme/Protease
作用靶點:NADPH Oxidase
In Vitro: VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM. VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells.
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