MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務。

Teplinovivint

CAS No. : 1428064-91-8

產品活性：Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research.

研究領域：Stem Cell/Wnt

作用靶點：Wnt  |  β-catenin

In Vitro: Teplinovivint (compound 175; 0.0003-10 μM) inhibits Wnt/p-catenin activity in human colorectal cancecell line (SW480) in a dose-dependent manner (EC₅₀=152.9 nM).
Teplinovivint inhibits SW480 cells (EC₅₀=25 nM) and primary human mesenchymal stem cells (hMSCs; EC₅₀=10.377 μM).
Teplinovivint (5.8, 10.8, 21.7, 41.7, 83.3, 166.6, 333.3, 750 nM) induced the expression of SCXA, TenacinC and Tenomodulin, in a dose-dependent manner with an EC₅₀ between 139-189 nM.

In Vivo: Teplinovivint (compound 175; 10 mg/ml; once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration. Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model.
Teplinovivint (1 mg/ml with 1% BA) has a T_max of 1 hours in plasma.

相關產品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Cytoskeleton Compound Library  |  Neuroprotective Compound Library  |  Anti-Breast Cancer Compound Library  |  Transcription Factor-Targeted Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Antihypertensive Compound Library  |  Membrane Protein-targeted Compound Library  |  CDK8-IN-11  |  FzM1  |  Wnt/β-catenin agonist 3 hydrochloride  |  Pamidronic acid  |  NRX-252114  |  Fz7-21  |  NSC668036  |  JW67  |  Ipafricept  |  (E)-Ferulic acid  |  Ipivivint  |  UU-T01  |  JW74  |  IQ 1  |  Heparan Sulfate  |  L-Quebrachitol  |  ETC-159  |  HLY78  |  Wnt/β-catenin agonist 2  |  Cardiogenol C hydrochloride  |  Laduviglusib (GMP)  |  FzM1.8  |  OM-153  |  iCRT-5  |  NRX-252262  |  NLS-StAx-h TFA  |  UU-T02  |  Wnt/β-catenin agonist 4  |  Wnt-C59  |  Wogonin

熱門產品線：重組蛋白  |  化合物庫  |  天然產物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種*僅有化合物庫，我們致力于為*科研客戶提供前沿的高品質小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領；
•   產品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產品，廣泛應用于新藥研發、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業技術服務；
•   設有專業的實驗中心和嚴格的質控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
•   產品的生物活性多經各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業團隊跟蹤最新的制藥及生命科學研究進展，為您提供*新的活性化合物；
•   與世界各大制藥公司及著名科研機構建立了長期的合作。