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當(dāng)前位置:BPS Bioscience Inc.>>Inhibitors / Activators>> 27766-2NVP-BEP800
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產(chǎn)品型號(hào)27766-2
品 牌BPS Bioscience
廠商性質(zhì)生產(chǎn)商
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更新時(shí)間:2023-11-11 08:48:19瀏覽次數(shù):107次
聯(lián)系我時(shí),請(qǐng)告知來(lái)自 化工儀器網(wǎng)NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Hsp90. NVP-BEP800 (also known as VER-82576) is a novel ATP-competitive HSP90β inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Heat shock protein 90 (Hsp90). NVP-BEP800 induced robust antitumor responses in tumor xenograft models, including regression in the BT-474 breast cancer model. NVP-BEP800 can radiosensitise tumour cell lines of different entities through destabilisation and depletion of several Hsp90 client proteins, thus causing the depletion of S phase and G2/M arrest, increased DNA damage and repair protraction and, to some extent, apoptosis.
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