The STAT3 Luciferase Reporter THP-1 cell line monitors the STAT3 (Signal Transducer and Activator of Transcription 3) signal transduction pathway. It contains a firefly luciferase gene driven by STAT3 response elements located upstream of the minimal TATA promoter. After activation by cytokines or growth factors, the endogenous transcription factor STAT3 binds to the DNA response elements, inducing transcription of the luciferase reporter gene.

These cells respond to IL-6 (Interleukin 6), to G-CSF (Granulocyte Colony-Stimulating Factor) and to IFN-γ (Interferon γ).

Figure 1: Illustration of STAT3 Luciferase Reporter THP-1 Cell Line reporter expression.
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