Description :The plaet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in plaet α-granules and are released upon plaet activation. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.

Catalog #:100-00CC

Source :E.coli

Purity :Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Biological Activity :Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED 50 for this effect is 15-20 ng/ml.

AA Sequence :MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG

PubMed Link :PDGF-CC

Country of Origin :USA

Recombinant Protein 100-00AB 100-00AB-2 Human PDGF-AB 2ug Mini
Recombinant Protein 100-00AB 100-00AB-10 Human PDGF-AB 10ug Standard
Recombinant Protein 100-00AB 100-00AB-100 Human PDGF-AB 100ug Bulk
Recombinant Protein 100-00AB 100-00AB-250 Human PDGF-AB 250ug Bulk
Recombinant Protein 100-00AB 100-00AB-500 Human PDGF-AB 500ug Bulk
Recombinant Protein 100-00AB 100-00AB-1000 Human PDGF-AB 1000ug Bulk
Recombinant Protein 100-00CC 100-00CC-5 Human PDGF-CC 5ug Mini
Recombinant Protein 100-00CC 100-00CC-20 Human PDGF-CC 20ug Standard
Recombinant Protein 100-00CC 100-00CC-100 Human PDGF-CC 100ug Bulk
Recombinant Protein 100-00CC 100-00CC-250 Human PDGF-CC 250ug Bulk
Recombinant Protein 100-00CC 100-00CC-500 Human PDGF-CC 500ug Bulk
Recombinant Protein 100-00CC 100-00CC-1000 Human PDGF-CC 1000ug Bulk
Recombinant Protein 100-01 100-01-5 Human sCD22 5ug Mini
Recombinant Protein 100-01 100-01-20 Human sCD22 20ug Standard
Recombinant Protein 100-01 100-01-100 Human sCD22 100ug Bulk
Recombinant Protein 100-01 100-01-250 Human sCD22 250ug Bulk
Recombinant Protein 100-01 100-01-500 Human sCD22 500ug Bulk
Recombinant Protein 100-01 100-01-1000 Human sCD22 1000ug Bulk
Recombinant Protein 100-03 100-03-10 Human Heregulin beta-1 10ug Mini
Recombinant Protein 100-03 100-03-50 Human Heregulin beta-1 50ug Standard
Recombinant Protein 100-03 100-03-100 Human Heregulin beta-1 100ug Bulk
Recombinant Protein 100-03 100-03-250 Human Heregulin beta-1 250ug Bulk
Recombinant Protein 100-03 100-03-500 Human Heregulin beta-1 500ug Bulk
Recombinant Protein 100-03 100-03-1000 Human Heregulin beta-1 1000ug Bulk
Recombinant Protein 100-04 100-04-5 Human Epiregulin 5ug Mini
Recombinant Protein 100-04 100-04-25 Human Epiregulin 25ug Standard
Recombinant Protein 100-04 100-04-100 Human Epiregulin 100ug Bulk
Recombinant Protein 100-04 100-04-250 Human Epiregulin 250ug Bulk
Recombinant Protein 100-04 100-04-500 Human Epiregulin 500ug Bulk
Recombinant Protein 100-04 100-04-1000 Human Epiregulin 1000ug Bulk
Recombinant Protein 100-05 100-05-5 Human IGF Binding Protein-5 5ug Mini
Recombinant Protein 100-05 100-05-25 Human IGF Binding Protein-5 25ug Standard
Recombinant Protein 100-05 100-05-100 Human IGF Binding Protein-5 100ug Bulk
Recombinant Protein 100-05 100-05-250 Human IGF Binding Protein-5 250ug Bulk
Recombinant Protein 100-05 100-05-500 Human IGF Binding Protein-5 500ug Bulk
Recombinant Protein 100-05 100-05-1000 Human IGF Binding Protein-5 1000ug Bulk
Recombinant Protein 100-06 100-06-5 Human PLGF-1 5ug Mini
Recombinant Protein 100-06 100-06-25 Human PLGF-1 25ug Standard
Recombinant Protein 100-06 100-06-100 Human PLGF-1 100ug Bulk
Recombinant Protein 100-06 100-06-250 Human PLGF-1 250ug Bulk
Recombinant Protein 100-06 100-06-500 Human PLGF-1 500ug Bulk
Recombinant Protein 100-06 100-06-1000 Human PLGF-1 1000ug Bulk
Recombinant Protein 100-07 100-07-10 Human Prolactin 10ug Mini
Recombinant Protein 100-07 100-07-50 Human Prolactin 50ug Standard
Recombinant Protein 100-07 100-07-100 Human Prolactin 100ug Bulk
Recombinant Protein 100-07 100-07-250 Human Prolactin 250ug Bulk
Recombinant Protein 100-07 100-07-500 Human Prolactin 500ug Bulk
Recombinant Protein 100-07 100-07-1000 Human Prolactin 1000ug Bulk
Recombinant Protein 100-08 100-08-5 Human IGF Binding Protein-3 5ug Mini
Recombinant Protein 100-08 100-08-25 Human IGF Binding Protein-3 25ug Standard
Recombinant Protein 100-08 100-08-100 Human IGF Binding Protein-3 100ug Bulk
Recombinant Protein 100-08 100-08-250 Human IGF Binding Protein-3 250ug Bulk
Recombinant Protein 100-08 100-08-500 Human IGF Binding Protein-3 500ug Bulk
Recombinant Protein 100-08 100-08-1000 Human IGF Binding Protein-3 1000ug Bulk
Recombinant Protein 100-09 100-09-10 Human PTHrp 10ug Mini