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塔望科技提供全系列的動物實驗用低/高氧控制產(chǎn)品，包括恒定濃度控制的低氧動物箱、高氧動物箱、可編程的間歇氧濃度控制系統(tǒng)、帶緩沖閘的低氧箱等。整套低氧/高氧實驗箱裝置主要由氧氣控制器和動物實驗箱兩部分組成。另可提供多種不同的氣體控制器，滿足不同實驗O2、CO2、NO、CO、O3等氣體濃度控制的需求。

Ox-100 動物低氧高氧實驗系統(tǒng)為動物低氧、高氧實驗?zāi)Ｐ偷慕⑻峁┖线m的氧氣環(huán)境，可用于模擬生物體內(nèi)的生理性低氧狀態(tài)，使體外研究結(jié)果更接近于體內(nèi)的真實水平；或用于模擬生物體處于的特殊低氧/高氧時的病理狀態(tài)，以便進(jìn)行相關(guān)機理及疾病的研究。可以進(jìn)行編程式的間歇低氧高氧濃度控制，實現(xiàn)低氧高氧交替實驗。

Ox-100 動物低氧高氧實驗系統(tǒng)產(chǎn)品特點及參數(shù)：

1. 為動物低氧、高氧實驗?zāi)Ｐ偷慕⑻峁┖线m的氣體環(huán)境

2. 按照設(shè)定氣體濃度自動配比氣體，維持恒定的氧氣濃度環(huán)境。無需在箱體外混合比例氣體，確保實驗氧濃度的穩(wěn)定，節(jié)省氣源

3. 動態(tài)可編程控制的氧濃度實驗箱，實現(xiàn)高氧、缺氧間歇交替控制

4. 采用進(jìn)口透明聚丙烯酸甲酯板（PMMA）材質(zhì)，堅固耐用

5. 7英寸大屏觸摸屏控制，人性化界面，操作簡單。

6. 監(jiān)測參數(shù)：溫度、濕度、氧氣O2濃度。

7. 非色散紅外（NDIR）二氧化碳傳感器，測量范圍：0～5000ppm測量精度：±30ppm

8. 進(jìn)口電化學(xué)氧氣O2濃度檢測器，測量范圍：0-100%vol，測量分辨率：0.01%，線性度好，檢測準(zhǔn)確、使用壽命長。具有溫度補償機制。

9. 溫度檢測：進(jìn)口高精度數(shù)字鉑電阻溫度傳感器

10. 氧氣濃度變化動態(tài)曲線，直觀了解氧氣濃度變化的過程

11. 氧氣濃度自動校準(zhǔn)：通過上位機程序?qū)鞲衅骺焖傩?zhǔn)

12. 濕度傳感器和除濕設(shè)計，能有效的降低動物實驗過程中呼吸產(chǎn)生的水汽對動物的影響。

13. 氣體混合及循環(huán)機制，保證箱體內(nèi)氣體濃度的均一。

14. 高性能電磁閥，性能穩(wěn)定，超長壽命＞1000萬次

可進(jìn)行以急性高氧實驗、急性缺氧實驗、慢性缺氧實驗、高氧/低氧交替實驗。

應(yīng)用領(lǐng)域

基因表達(dá)研究：有研究表明，基因組中5%的基因表達(dá)是受氧氣濃度調(diào)控的；

腫瘤生物學(xué)：迅速增殖的腫瘤內(nèi)部的細(xì)胞，常處于低氧微環(huán)境中；

神經(jīng)生物學(xué)：低氧狀態(tài)下神經(jīng)細(xì)胞的增殖、分化及損傷研究；

睡眠呼吸暫停綜合癥、心肌缺血缺氧、腦缺血損傷、肺動脈高壓、高原反應(yīng)、腫瘤、眼科疾病、呼吸疾病、造血功能等多種領(lǐng)域的動物建模研究。

相關(guān)文獻(xiàn)

[1]Xu Y, Kong X, Li J, Cui T, Wei Y, Xu J, Zhu Y , Zhu X. “Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys." [J]. Front. Physiol. 12:690496. doi: 10.3389/fphys.2021.690496

[2]Liang Xie, Qinhan Wu, Weiping Hu, Xu Wu, Guiling Xiang, Shengyu Hao, Han Guo, Shanqun Li. “Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions." [J]. Psychopharmacology.

[3]Li Huang, Tianyou Li, Min Zhou, Mengyan Deng, Lidong Zhang, Long Yi, Jundong Zhu, Xiaohui Zhu, Mantian Mi. “Hypoxia Improves Endurance Performance by Enhancing Short Chain Fatty Acids Production via Gut Microbiota Remodeling." [J]. Front. Microbiol. 12:820691

[4]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[5]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway" .[J]. Frontiers in Pharmacology,10.3389/fphar.2022.920977

[7]Chenyu Xu, Jun Xu, Chunfang Zou, Qian Li, Shan Mao, Ying Shi, Yan Tan, Wei Gu, Liang Ye. "Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm."  [J]. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 2502324, 15 pages

[8]Jing Zhang, Jian-Zhong Jiang, Jun Xu, Chen-Yu Xu, Shan Mao, Ying Shi, Wei Gu, Chun-Fang Zou, Yue-Ming Zhao,  Liang Ye. "Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea." [J].  Elsevier Inc. This is an open access article under the CC BY-NC-ND license

[9]Zhang Q, Xu L, Bai Y, Chen P, Xing M, Cai F, Wu Y,  Song W. “Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation." [J]. Front. Mol. Neurosci. 16:1155047.

[10]Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension." [J]. Cell Death Discovery (2023) 9:98.

[11]Chen-Yu Jiang,Li-Wei Wu,Yi-Wei Liu,Bei Feng, Lin-Cai Ye,Xu Huang,Yang-Yang He,Yi Shen, Yi-Fan Zhu, Xing-Liang Zhou, Dai-Ji Jiang, Hai-Kun Qi, Hao Zhang, and Yi Yan.Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension,[J]Frontiers in?Immunology,28 June 2023,Volume 14 - 2023, DOI: 10.3389/fimmu.2023.1153573

[12]Haimei Lun, Ruochuan Liu, Qiao Hu, Yaoli Liu, Lisi Wei, Xia Liu, Dan Wu, Shangyong Zhu,Contrast?Enhanced?Ultrasonography?of?Kidney?in?Chronic?Intermittent?Hypoxia?Rat?Model,[J]Journal of Ultrasound in Medicine,2022-12-07 ,DOI:10.1002/jum.16147

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