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Source

Rabbit

Applications

IHC,ELISA

Reactivity

Human

Dilution

IHC 1:50-200, ELISA 1:10000-20000

Storage

-20°C/1 year

Specificity

The antibody detects endogenous CD274

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

Synthetic peptide from human protein at AA range: 181-230

Uniprot No

Q9NZQ7

Alternative names

Programmed cell death 1 ligａnd 1 (PD-L1) (PDCD1 ligａnd 1) (Programmed death ligａnd 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

CD274 molecule(CD274) Homo sapiens This gene encodes an immune inhibitory receptor ligａnd that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligａnd with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

Other

CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1, Programmed cell death 1 ligａnd 1 (PD-L1) (PDCD1 ligａnd 1) (Programmed death ligａnd 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)

Concentration

1 mg/ml