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Source

Mouse

Applications

WB,IHC,

Reactivity

Human

Dilution

WB: 1:1000 IHC 1:50-300

Storage

-20°C/1 year

Specificity

The antibody detects endogenous CD16 protein.

Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen

Synthetic Peptide of CD16

Uniprot No

P08637/O75015

Form

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Clonality

Monoclonal

Isotype

IgG

Background

Fc fragment of IgG receptor IIIa(FCGR3A) Homo sapiens This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq,

Other

FCGR3A/FCGR3B, Low affinity immunoglobulin gamma Fc region receptor III-A/Low affinity immunoglobulin gamma Fc region receptor III-B

Mol.Wt (Da)

27940

Concentration

1 mg/ml