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Source

Mouse

Applications

WB,IHC,IF,IP

Reactivity

Human,Mouse,Rat,chicken

Dilution

WB: 1:1000-5000 IP:1:200 IF 1:200 IHC 1:50-300

Storage

-20°C/1 year

Specificity

The antibody detects endogenous Caspase 9 protein.

Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen

Synthetic Peptide of Caspase 9

Uniprot No

P55211

Alternative names

CASP9; MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6

Form

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Clonality

Monoclonal

Isotype

IgG

Background

caspase 9(CASP9) Homo sapiens This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013],

Other

CASP9, Caspase-9

Mol.Wt (Da)

46281

Concentration

1 mg/ml