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Source

Rabbit

Applications

WB

Reactivity

Human,Mouse,Rat

Dilution

WB 1:1000-2000

Storage

-20°C/1 year

Specificity

This antibody detects endogenous levels of Human Mouse Rat CARD11 (phospho-Ser652)

Source/Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen

Synthesized phosho peptide around human CARD11 (Ser652)

Uniprot No

Q9BXL7

Alternative names

Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

caspase recruitment domain family member 11(CARD11) Homo sapiens The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],

Other

CARD11 CARMA1, CARD11 (Ser652)

Concentration

1 mg/ml