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Source

Rabbit

Applications

WB,ELISA

Reactivity

Human

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Storage

-20°C/1 year

Specificity

CAMLG Polyclonal Antibody detects endogenous levels of protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

Synthesized peptide derived from part region of human protein

Uniprot No

P49069

Form

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

calcium modulating ligand(CAMLG) Homo sapiens The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008],

Other

CAMLG CAML, Calcium signal-modulating cyclophilin ligａnd (CAML)

Concentration

1 mg/ml