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Source

Rabbit

Applications

IHC,ELISA

Reactivity

Human,Mouse,Rat

Dilution

IHC: 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

Phospho-Caldesmon (S759) Polyclonal Antibody detects endogenous levels of Caldesmon protein only when phosphorylated at S759.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human Caldesmon around the phosphorylation site of Ser759. AA range:725-774

Uniprot No

Q05682

Alternative names

CALD1; CAD; CDM; Caldesmon; CDM

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

caldesmon 1(CALD1) Homo sapiens This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],

Other

CALD1, Caldesmon

Mol.Wt (Da)

high molecular weight (predominantly in smooth muscles) (120-150 KD) and a low molecular weight (60-90KD)

Concentration

1 mg/ml