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Source

Rabbit

Applications

WB, ELISA

Reactivity

Human

Dilution

WB 1:500-2000, ELISA(peptide)1:5000-20000

Storage

-20°C/1 year

Specificity

This antibody detects endogenous levels of human Alix

Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogen

Synthesized peptide derived from human Alix

Uniprot No

Q8WUM4

Alternative names

Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95)

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

programmed cell death 6 interacting protein(PDCD6IP) Homo sapiens This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012],

Other

PDCD6IP AIP1 ALIX KIAA1375, Alix

Concentration

1 mg/ml