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Source

Rabbit

Applications

WB,IHC,IF,ELISA

Reactivity

Human,Mouse,Rat

Dilution

WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. IF: 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Storage

-20°C/1 year

Specificity

3pK Polyclonal Antibody detects endogenous levels of 3pK protein.

Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen

The antiserum was produced against synthesized peptide derived from human MAPK3. AA range:301-350

Uniprot No

Q16644

Alternative names

MAPKAPK3; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3; Chromosome 3p kinase; 3pK

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

mitogen-activated protein kinase-activated protein kinase 3(MAPKAPK3) Homo sapiens This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and

Other

MAPKAPK3, MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3

Mol.Wt (Da)

42987

Concentration

1 mg/ml