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Norepinephrine hydrochloride

產品活性：Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride 是一種有效的腎上腺素能受體 (AR) 激動劑。Norepinephrine 可以激活 α₁、α₂、β₁ 受體。

研究領域：GPCR/G Protein  |  Neuronal Signaling  |  Autophagy  |  Metabolic Enzyme/Protease

作用靶點：Adrenergic Receptor  |  Autophagy  |  Endogenous Metabolite

結構分類：生物堿  |  其他類生物堿  |  酚類  |  多酚類

來源：植物  |  豆科  |  含羞草

In Vitro: Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is generally considered to be a β₁-subtype selective adrenergic agonist over β₂-adrenoceptor. Norepinephrine(NE) hydrochloride also has direct activity at the β₂-adrenoceptor in higher concentrations.
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA.

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