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BPS Bioscience Inc.
中級(jí)會(huì)員 | 第3年

當(dāng)前位置:BPS Bioscience Inc.>>技術(shù)服務(wù)>>檢測(cè)相關(guān)>> BPS Bioscience的甲基轉(zhuǎn)移酶篩選和檢測(cè)服務(wù)

BPS Bioscience的甲基轉(zhuǎn)移酶篩選和檢測(cè)服務(wù)

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品       牌BPS Bioscience

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更新時(shí)間:2023-12-19 23:38:49瀏覽次數(shù):335次

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提供商:BPSBioscience服務(wù)名稱(chēng):BPSBioscience的甲基轉(zhuǎn)移酶篩選和檢測(cè)服務(wù)MethyltransferasesareenzymesthattransferamethylgroupfromS-adenosylmethionine(SAM)tosubstratemolecules
  • 提供商:

    BPS Bioscience

  • 服務(wù)名稱(chēng):

    BPS Bioscience的甲基轉(zhuǎn)移酶篩選和檢測(cè)服務(wù)

Methyltransferases are enzymes that transfer a methyl group from S-adenosylmethionine (SAM) to substrate molecules, such as DNA, RNA, and proteins. In particular, methylation of lysines or arginines in histone tails provides epigenetic regulation of gene expression, in which methyltransferases serve as the “writers" of the methylation code on histones. The degree of methylation and the location of methylation induce conformational changes in chromatin that enable or suppress access by the transcriptional machinery to express genes. DNA methyltransferases modify DNA by adding a methyl group to cytosines. DNA methylation of CpG dinucleotides suppresses gene expression and is critical for transcriptional silencing during imprinting, X-inactivation and other developmental processes. Both histone and DNA methylation play a crucial role in the development of nearly all types of cancer and are targets for therapy.

We offer an extensive selection of RNA, DNA, and histone methyltransferase target screening and profiling services. Our team of experts, using our in-house developed biochemical assay kits, can provide:

  • Screening for activity and selectivity across our full panel or just select targets

  • Determination of IC50

  • Project guidance and questions answered in a timely manner

  • Delivery of detailed results promptly and on time

If follow-up studies are required, we can provide the same active proteins as the ones used in our assays.

圖片

Available Service Assays

DNA Methyltransferase Biochemical Assays:

DNMT1DNMT3A/DNMT3LDNMT3B/DNMT3L

Histone Methyltransferase Biochemical Assays:

DOT1L
EZH1
EZH2
EZH2 (A677G)
EZH2 (A738T)
EZH2 del153YEZH2-EED
EZH2 (P132S)EZH2 (R679C)
EZH2 (Y641C)
EZH2 (Y641F)
EZH2 (Y641H)
EZH2 (Y641N)
EZH2 (Y641S)

G9a
GLP
MLL1 (WARD) Complex
MLL3 (WARD) Complex
MLL4 (WARD) Complex
NSD1
NSD2NSD3
PRDM9
PRMT1
PRMT3
PRMT4
PRMT5
PRMT6

PRMT7
PRMT7(Automethlyation)
PRMT8
PRMT9
SETDB1
SETD2
SET7/9
SET8SMYD2
SMYD3
SMYD4SUV39H1
SUV39H2
SUV4-20H1

RNA Methyltransferase Biochemical Assays:

METTL3/METTL14 Complex

如果您需要了解更多關(guān)于我們的服務(wù)的信息,請(qǐng)聯(lián)系info。

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